complex I of electron transport chain
GPTKB entity
Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:NADH:ubiquinone_oxidoreductase
NADH dehydrogenase |
| gptkbp:cofactor |
gptkb:FMN
iron-sulfur clusters |
| gptkbp:component |
electron transport chain
|
| gptkbp:EC_number |
1.6.5.3
|
| gptkbp:foundIn |
eukaryotes
some bacteria |
| gptkbp:function |
pumps protons across mitochondrial membrane
transfers electrons from NADH to ubiquinone |
| gptkbp:gene |
multiple nuclear and mitochondrial genes
|
| https://www.w3.org/2000/01/rdf-schema#label |
complex I of electron transport chain
|
| gptkbp:inhibitedBy |
gptkb:piericidin_A
gptkb:rotenone amytal |
| gptkbp:locatedIn |
inner mitochondrial membrane
|
| gptkbp:molecularWeight |
~980 kDa in mammals
|
| gptkbp:mutationAssociatedWith |
gptkb:Leigh_syndrome
mitochondrial diseases |
| gptkbp:powerSource |
contributes to proton gradient for ATP synthesis
|
| gptkbp:step |
mitochondrial electron transport chain
|
| gptkbp:substrate |
gptkb:NADH
ubiquinone (coenzyme Q) |
| gptkbp:subunit |
at least 45 protein subunits in mammals
|
| gptkbp:bfsParent |
gptkb:NADH
|
| gptkbp:bfsLayer |
6
|