superoxide dismutase 2 (SOD2)

URI: https://gptkb.org/entity/superoxide_dismutase_2_(SOD2)
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:MnSOD
gptkbp:associatedWith gptkb:cancer
amyotrophic lateral sclerosis
cardiomyopathy
gptkbp:biologicalProcess antioxidant activity
response to oxidative stress
gptkbp:cofactor manganese
gptkbp:discoveredBy gptkb:Irwin_Fridovich
gptkbp:discoveredIn 1969
gptkbp:EC_number 1.15.1.1
gptkbp:encodedBy gptkb:SOD2_gene
gptkbp:Entrez_Gene_ID 6648
gptkbp:function catalyzes dismutation of superoxide radicals
gptkbp:gene gptkb:SOD2
gptkbp:HGNC_ID 11180
https://www.w3.org/2000/01/rdf-schema#label superoxide dismutase 2 (SOD2)
gptkbp:locatedIn mitochondrion
gptkbp:locatedOnChromosome chromosome 6q25.3
gptkbp:mutationAssociatedWith mitochondrial dysfunction
increased oxidative damage
gptkbp:OMIM 147460
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkbp:PDB gptkb:1LUV
gptkbp:RefSeq gptkb:NM_000636
gptkbp:structure homotetramer
gptkbp:subcellularLocation mitochondrial matrix
gptkbp:UniProtID P04179
gptkbp:bfsParent gptkb:SIRT3
gptkbp:bfsLayer 8