|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:ADP
|
|
gptkbp:alternativeName
|
gptkb:GDH
gptkb:L-glutamate_dehydrogenase
gptkb:glutamic_acid_dehydrogenase
|
|
gptkbp:catalyzes
|
oxidative deamination of glutamate to α-ketoglutarate
|
|
gptkbp:cofactor
|
NADP+
NAD+
|
|
gptkbp:discoveredBy
|
gptkb:Sir_Hans_Adolf_Krebs
|
|
gptkbp:EC_number
|
1.4.1.2
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
pancreas
|
|
gptkbp:foundIn
|
gptkb:Bacteria
gptkb:cytoplasm
animals
plants
mitochondria
|
|
gptkbp:gene
|
gptkb:GLUD2
gptkb:GLUD1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
glutamate dehydrogenase
|
|
gptkbp:human_chromosome
|
10 (GLUD1)
X (GLUD2)
|
|
gptkbp:inhibitedBy
|
gptkb:ATP
gptkb:GTP
|
|
gptkbp:molecularWeight
|
~56 kDa (per subunit)
|
|
gptkbp:presentIn
|
prokaryotes
eukaryotes
|
|
gptkbp:product
|
gptkb:α-ketoglutarate
gptkb:H+
gptkb:NADH
ammonia
NADPH
|
|
gptkbp:proteinFamily
|
oxidoreductase
|
|
gptkbp:reaction_direction
|
reversible
|
|
gptkbp:regulates
|
allosteric
|
|
gptkbp:role
|
gptkb:urea_cycle
amino acid metabolism
nitrogen metabolism
TCA cycle
gluconeogenesis
|
|
gptkbp:significance
|
gptkb:hyperinsulinism-hyperammonemia_syndrome
liver disease marker
|
|
gptkbp:structure
|
hexamer
|
|
gptkbp:substrate
|
gptkb:water
gptkb:L-glutamate
NADP+
NAD+
|
|
gptkbp:bfsParent
|
gptkb:L-glutamate
gptkb:alpha-ketoglutaric_acid
|
|
gptkbp:bfsLayer
|
7
|