|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SIR2L3
SIR2-like 3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
aging
metabolic regulation
|
|
gptkbp:discoveredIn
|
2000s
|
|
gptkbp:encodes
|
Sirtuin 3 protein
|
|
gptkbp:Entrez_Gene_ID
|
23410
ENSG00000142082
|
|
gptkbp:expressedIn
|
mitochondria
|
|
gptkbp:function
|
NAD-dependent deacetylase activity
regulation of mitochondrial function
|
|
gptkbp:HGNC_ID
|
14922
|
|
gptkbp:length
|
~15 kb
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:location
|
gptkb:11p15.5
|
|
gptkbp:mutationAssociatedWith
|
gptkb:metabolic_syndrome
hearing loss
|
|
gptkbp:numberOfExons
|
9
|
|
gptkbp:OMIM
|
604479
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Sirt3
|
|
gptkbp:product
|
gptkb:SIRT3
|
|
gptkbp:proteinFamily
|
sirtuin family
|
|
gptkbp:regulates
|
gptkb:FOXO3a
gptkb:PGC-1α
energy metabolism
oxidative stress response
acetylation of mitochondrial proteins
|
|
gptkbp:UniProtID
|
gptkb:Q9NTG7
|
|
gptkbp:bfsParent
|
gptkb:SIRT3
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SIRT3 gene
|