SHC (Src Homology 2 Domain Containing) Transforming Protein 1

URI: https://gptkb.org/entity/SHC_(Src_Homology_2_Domain_Containing)_Transforming_Protein_1
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:SHC-transforming_protein_1
gptkb:p46Shc
gptkb:p52Shc
gptkb:p66Shc
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkbp:discoveredBy Tomaselli et al.
gptkbp:discoveredIn 1992
gptkbp:domain SH2 domain
PTB domain
gptkbp:Entrez_Gene_ID gptkb:ENSG00000180008
GC01M155073
gptkbp:expressedIn gptkb:cancer
gptkb:kidney
brain
heart
liver
gptkbp:function signal transduction
adaptor protein
gptkbp:gene gptkb:SHC1
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 10840
https://www.w3.org/2000/01/rdf-schema#label SHC (Src Homology 2 Domain Containing) Transforming Protein 1
gptkbp:interactsWith gptkb:EGFR
gptkb:Grb2
gptkb:RET
gptkb:SOS1
gptkb:IRS1
gptkbp:involves gptkb:MAPK/ERK_pathway
insulin signaling pathway
gptkbp:locatedOnChromosome gptkb:chromosome_1q21
gptkbp:molecularWeight 52 kDa
46 kDa
66 kDa
gptkbp:OMIM 600852
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse Shc1
gptkbp:phosphorylates gptkb:tyrosine
serine
gptkbp:RefSeq NM_001267550
NM_001267551
NM_183001
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:UniProtID gptkb:P29353
gptkbp:bfsParent gptkb:SHC1
gptkbp:bfsLayer 7