SHC-transforming protein 1

URI: https://gptkb.org/entity/SHC-transforming_protein_1
GPTKB entity
Statements (46)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias gptkb:SHC1
gptkb:p46Shc
gptkb:p52Shc
gptkb:p66Shc
gptkbp:alternativeSplicing gptkb:p46Shc
gptkb:p52Shc
gptkb:p66Shc
gptkbp:associatedWith gptkb:cancer
gptkb:cardiovascular_disease
aging
gptkbp:domain SH2 domain
PTB domain
CH1 domain
gptkbp:encodedBy gptkb:SHC1_gene
gptkbp:Entrez_Gene_ID 6464
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function signal transduction
adaptor protein
https://www.w3.org/2000/01/rdf-schema#label SHC-transforming protein 1
gptkbp:interactsWith gptkb:EGFR
gptkb:Insulin_receptor
gptkb:Grb2
gptkb:RET
gptkb:SOS1
gptkbp:involvedIn gptkb:MAPK/ERK_pathway
gptkbp:length 584 amino acids (p66Shc isoform)
gptkbp:locatedOnChromosome 1q21
gptkbp:molecularWeight 46-66 kDa
gptkbp:OMIM 600837
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 1SHC
gptkbp:phosphorylates tyrosine residues
gptkbp:postTranslationalModification phosphorylation
oxidation
gptkbp:role cell proliferation
angiogenesis
oxidative stress response
apoptosis regulation
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
mitochondria
gptkbp:UniProtID gptkb:P29353
gptkbp:bfsParent gptkb:SHC1
gptkbp:bfsLayer 7