SHC-transforming protein 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alias	gptkb:SHC1 gptkb:p46Shc gptkb:p52Shc gptkb:p66Shc
gptkbp:alternativeSplicing	gptkb:p46Shc gptkb:p52Shc gptkb:p66Shc
gptkbp:associatedWith	gptkb:cancer gptkb:cardiovascular_disease aging
gptkbp:domain	SH2 domain PTB domain CH1 domain
gptkbp:encodedBy	gptkb:SHC1_gene
gptkbp:Entrez_Gene_ID	6464
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	signal transduction adaptor protein
gptkbp:interactsWith	gptkb:EGFR gptkb:Insulin_receptor gptkb:Grb2 gptkb:RET gptkb:SOS1
gptkbp:involvedIn	gptkb:MAPK/ERK_pathway
gptkbp:length	584 amino acids (p66Shc isoform)
gptkbp:locatedOnChromosome	1q21
gptkbp:molecularWeight	46-66 kDa
gptkbp:OMIM	600837
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	1SHC
gptkbp:phosphorylates	tyrosine residues
gptkbp:postTranslationalModification	phosphorylation oxidation
gptkbp:role	cell proliferation angiogenesis oxidative stress response apoptosis regulation
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm mitochondria
gptkbp:UniProtID	gptkb:P29353
gptkbp:bfsParent	gptkb:SHC1
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	SHC-transforming protein 1