|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SHC-transforming_protein_1
gptkb:p46Shc
gptkb:p52Shc
gptkb:p66Shc
gptkb:SHC
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
aging
|
|
gptkbp:discoveredBy
|
Pier Paolo Di Fiore
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:encodes
|
gptkb:SHC-transforming_protein_1
gptkb:p46Shc
gptkb:p52Shc
gptkb:p66Shc
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000180008
6464
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
SHC adaptor protein 1
|
|
gptkbp:function
|
signal transduction
adaptor protein
|
|
gptkbp:HGNC_ID
|
10840
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SHC1 gene
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
cell proliferation
oxidative stress response
apoptosis regulation
insulin signaling pathway
|
|
gptkbp:locatedOnChromosome
|
1
1q21.2
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
altered cell signaling
altered lifespan in model organisms
|
|
gptkbp:OMIM
|
600039
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Shc1 gene
rat Shc1 gene
|
|
gptkbp:proteinFamily
|
SH2 domain
PTB domain
CH1 domain
|
|
gptkbp:RefSeq
|
NM_183001
|
|
gptkbp:regulates
|
cellular response to growth factors
cellular response to oxidative stress
|
|
gptkbp:symbol
|
gptkb:SHC1
|
|
gptkbp:UniProtID
|
gptkb:P29353
|
|
gptkbp:bfsParent
|
gptkb:SHC-transforming_protein_1
gptkb:SHC1_protein
gptkb:p46Shc
gptkb:p52Shc
gptkb:p66Shc
gptkb:Shc
gptkb:Shc_protein
|
|
gptkbp:bfsLayer
|
8
|