mitotic checkpoint

GPTKB entity

Statements (21)
Predicate Object
gptkbp:instanceOf biological pathway
gptkbp:alsoKnownAs spindle assembly checkpoint
gptkbp:failureLeadsTo genomic instability
aneuploidy
gptkbp:guarantees proper chromosome attachment to spindle
https://www.w3.org/2000/01/rdf-schema#label mitotic checkpoint
gptkbp:inhibitedBy gptkb:anaphase-promoting_complex/cyclosome_(APC/C)
gptkbp:involves BUBR1 protein
BUB1 protein
CDC20 protein
MAD2 protein
MPS1 kinase
gptkbp:isActiveDuring mitosis
gptkbp:partOf cell cycle control
gptkbp:prevention chromosome missegregation
gptkbp:regulates progression from metaphase to anaphase
gptkbp:studiedIn cancer research
gptkbp:target anticancer drugs
gptkbp:bfsParent gptkb:Rb_protein
gptkb:SAC_(gene)
gptkbp:bfsLayer 7