|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:PHB
gptkb:BAP37
gptkb:HEL-215
|
|
gptkbp:associatedWith
|
gptkb:cancer
aging
|
|
gptkbp:conservedIn
|
eukaryotes
|
|
gptkbp:discoveredBy
|
1991
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000167085
5245
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:PHB2
|
|
gptkbp:fullName
|
gptkb:Prohibitin-1
|
|
gptkbp:function
|
regulation of cell proliferation
transcriptional regulation
mitochondrial chaperone
|
|
gptkbp:gene
|
gptkb:PHB1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PHB1
|
|
gptkbp:inhibitedBy
|
cell proliferation
apoptosis (context-dependent)
|
|
gptkbp:interactsWith
|
gptkb:Rb_protein
gptkb:p53
gptkb:PHB2
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:location
|
gptkb:17q21.33
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
prostate cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:yeast
right
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:promotion
|
mitochondrial integrity
|
|
gptkbp:regulates
|
cellular senescence
transcription factors
cellular metabolism
estrogen receptor activity
mitochondrial morphology
|
|
gptkbp:role
|
apoptosis
signal transduction
cell cycle regulation
mitochondrial biogenesis
|
|
gptkbp:structure
|
contains SPFH domain
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
mitochondria
|
|
gptkbp:UniProtID
|
gptkb:P35232
|
|
gptkbp:bfsParent
|
gptkb:Prohibitin
|
|
gptkbp:bfsLayer
|
6
|