|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activeWhen
|
bound to GTP
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:conservedIn
|
eukaryotes
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Weinberg
|
|
gptkbp:encodes
|
gptkb:Ras_proteins
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:function
|
molecular switch
|
|
gptkbp:gene
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS genes
|
|
gptkbp:inactiveWhen
|
bound to GDP
|
|
gptkbp:include
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:interactsWith
|
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:involvedIn
|
cell differentiation
cell survival
cell signaling
cell growth regulation
|
|
gptkbp:locatedOn
|
gptkb:chromosome_11_(HRAS)
gptkb:chromosome_12_(KRAS)
gptkb:chromosome_1_(NRAS)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
point mutation
codon 12
codon 13
codon 61
oncogenic transformation
high in colorectal cancer
high in lung adenocarcinoma
high in pancreatic cancer
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:product
|
guanine nucleotide exchange factor
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:studiedIn
|
developmental biology
signal transduction
cancer biology
|
|
gptkbp:target
|
farnesyltransferase inhibitors
direct KRAS inhibitors
|
|
gptkbp:bfsParent
|
gptkb:RAS_proteins
|
|
gptkbp:bfsLayer
|
6
|