|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:RAS_protein
|
|
gptkbp:discoveredIn
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:encodedBy
|
gptkb:RAS_gene_family
|
|
gptkbp:firstDescribed
|
1982
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
gptkbp:geneFamilyMembers
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:hasIsoform
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Rat sarcoma protein
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
cell signal transduction
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
gptkb:RAS_subfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
codon 12
codon 13
codon 61
oncogenic mutation
|
|
gptkbp:namedAfter
|
gptkb:rat_sarcoma_virus
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:regulates
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:structure
|
contains G domain
contains switch I and II regions
|
|
gptkbp:target
|
gptkb:KRAS_G12C_inhibitors
farnesyltransferase inhibitors
anticancer drugs
|
|
gptkbp:bfsParent
|
gptkb:Ras_protein
|
|
gptkbp:bfsLayer
|
6
|