|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
gptkb:Edward_M._Scolnick
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:KRAS_gene
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
gptkb:molecular_switch
GTPase activity
|
|
gptkbp:inhibitedBy
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:involves
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:locale
|
gptkb:plasma_membrane
|
|
gptkbp:memberOf
|
gptkb:small_GTPase_superfamily
|
|
gptkbp:molecularWeight
|
~21 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:ortholog_in_C._elegans
|
gptkb:let-60
|
|
gptkbp:ortholog_in_Drosophila
|
gptkb:Ras85D
|
|
gptkbp:PDB
|
gptkb:5P21
4Q21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell survival
cell growth
|
|
gptkbp:requires
|
embryonic development
|
|
gptkbp:structure
|
G domain
switch I region
switch II region
|
|
gptkbp:subfamily
|
gptkb:K-Ras
gptkb:H-Ras
gptkb:N-Ras
|
|
gptkbp:target
|
gptkb:Adagrasib
gptkb:Sotorasib
farnesyltransferase inhibitors
|
|
gptkbp:UniProtID
|
gptkb:P01111
gptkb:P01112
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:Ras/MAPK_signaling_pathway
gptkb:Ras_protein
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras GTPase
|