|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BCC7
gptkb:LFS1
gptkb:TRP53
P53
|
|
gptkbp:associatedWith
|
gptkb:Li-Fraumeni_syndrome
various cancers
|
|
gptkbp:biologicalProcess
|
DNA repair
apoptotic process
cell cycle arrest
protein binding
cellular response to stress
sequence-specific DNA binding
DNA-binding transcription factor activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:Entrez_Gene_ID
|
7157
|
|
gptkbp:fullName
|
gptkb:tumor_protein_p53
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:geneType
|
protein_coding
|
|
gptkbp:hasTranscript
|
gptkb:ENST00000269305
ENST00000413465
ENST00000420246
ENST00000445888
|
|
gptkbp:HGNC_ID
|
HGNC:11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ENSG00000141564
|
|
gptkbp:length
|
20,000 bp (approximate)
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:mutationAssociatedWith
|
loss of function leads to cancer
germline mutations cause Li-Fraumeni syndrome
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Trp53
gptkb:zebrafish_tp53
|
|
gptkbp:pathway
|
apoptosis
cell cycle
p53 signaling pathway
|
|
gptkbp:product
|
gptkb:cellular_tumor_antigen_p53
|
|
gptkbp:referenceGenome
|
gptkb:GRCh37
gptkb:GRCh38
|
|
gptkbp:regulates
|
activated by DNA damage
regulated by MDM2
|
|
gptkbp:strand
|
minus
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
P04637
|
|
gptkbp:bfsParent
|
gptkb:RPTOR
gptkb:Aatf
|
|
gptkbp:bfsLayer
|
7
|