|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD140b
Beta-type platelet-derived growth factor receptor
|
|
gptkbp:amendedBy
|
phosphorylation
glycosylation
|
|
gptkbp:associatedWith
|
gptkb:idiopathic_basal_ganglia_calcification
gptkb:chronic_myelomonocytic_leukemia
gptkb:infantile_myofibromatosis
|
|
gptkbp:discoveredBy
|
Andersson et al.
|
|
gptkbp:encodedBy
|
gptkb:PDGFRB_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113721
5159
|
|
gptkbp:expressedIn
|
fibroblasts
pericytes
vascular smooth muscle cells
|
|
gptkbp:fullName
|
gptkb:Platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
cell differentiation
angiogenesis
cell growth regulation
|
|
gptkbp:HGNC_ID
|
8804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRB protein
|
|
gptkbp:interactsWith
|
gptkb:PDGFA_protein
PDGFB protein
|
|
gptkbp:locatedOnChromosome
|
5q32
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~180 kDa
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
oncogenic transformation
|
|
gptkbp:OMIM
|
173410
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:PDB
|
5GRN
|
|
gptkbp:phosphorylates
|
Y1009
Y1021
Y751
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:structure
|
transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
|
|
gptkbp:target
|
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
|
|
gptkbp:UniProtID
|
gptkb:P09619
|
|
gptkbp:bfsParent
|
gptkb:Pdgfrb
|
|
gptkbp:bfsLayer
|
7
|