|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Antigen_NY-CO-13
gptkb:Phosphoprotein_p53
gptkb:Tumor_suppressor_p53
gptkb:Transformation-related_protein_53
|
|
gptkbp:associatedWith
|
gptkb:p63
gptkb:p73
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:disease_involvement
|
gptkb:Li-Fraumeni_syndrome
various cancers
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSP00000269305
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:function
|
tumor suppressor
transcription factor
|
|
gptkbp:gene
|
gptkb:TP53
|
|
gptkbp:GO_term
|
apoptotic process
cell cycle arrest
transcription regulation
DNA binding
|
|
gptkbp:hasIsoform
|
multiple
|
|
gptkbp:HGNC_ID
|
11998
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P35712
|
|
gptkbp:InterPro
|
gptkb:IPR002117
gptkb:IPR011615
IPR010991
|
|
gptkbp:KEGGID
|
gptkb:hsa:7157
|
|
gptkbp:length
|
393 amino acids
|
|
gptkbp:locatedOnChromosome
|
17
17p13.1
|
|
gptkbp:molecularWeight
|
43.7 kDa
|
|
gptkbp:mutationAssociatedWith
|
gain of function in some cancers
loss of function in cancer
|
|
gptkbp:OMIM
|
191170
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Trp53
gptkb:rat_Tp53
gptkb:zebrafish_tp53
|
|
gptkbp:pathway
|
apoptosis
DNA repair
cell cycle
p53 signaling pathway
|
|
gptkbp:PDB
|
gptkb:2OCJ
gptkb:3KMD
1TUP
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:protein_name
|
gptkb:Cellular_tumor_antigen_p53
|
|
gptkbp:proteinFamily
|
gptkb:p53_family
gptkb:PF00870
|
|
gptkbp:Reactome
|
R-HSA-69541
|
|
gptkbp:RefSeq
|
NP_000537.3
|
|
gptkbp:regulates
|
activated by DNA damage
regulated by ARF
regulated by MDM2
|
|
gptkbp:reviewedBy
|
yes
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniGene
|
Hs.476018
|
|
gptkbp:UniProt_entry_name
|
gptkb:P53_HUMAN
|
|
gptkbp:UniProtID
|
gptkb:P35712
|
|
gptkbp:bfsParent
|
gptkb:SOX6
|
|
gptkbp:bfsLayer
|
7
|