|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Tumor necrosis factor alpha
Cachectin
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
Psoriasis
Rheumatoid arthritis
Inflammatory bowel disease
Septic shock
|
|
gptkbp:biologicalProcess
|
immune response
apoptotic process
inflammatory response
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
extracellular region
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:enzyme
|
ADAM17 (cleaves membrane form to soluble form)
|
|
gptkbp:expressedIn
|
T lymphocytes
Endothelial cells
Macrophages
Fibroblasts
Natural killer cells
|
|
gptkbp:fullName
|
gptkb:Tumor_necrosis_factor
|
|
gptkbp:function
|
Cytokine involved in systemic inflammation
Induces apoptotic cell death
Involved in immune system regulation
Mediates inflammation
|
|
gptkbp:gene
|
gptkb:TNF
|
|
gptkbp:goMolecularFunction
|
cytokine activity
receptor binding
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFA HUMAN
|
|
gptkbp:locatedOnChromosome
|
6p21.33
|
|
gptkbp:molecularWeight
|
25.6 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
TNFA_MOUSE
TNFA_RAT
|
|
gptkbp:pathway
|
gptkb:TNF_signaling_pathway
Apoptosis
NF-kappa B signaling pathway
|
|
gptkbp:PDB
|
gptkb:1TNF
gptkb:2TNF
gptkb:3TNF
|
|
gptkbp:postTranslationalModification
|
Disulfide bond
Glycosylation
Cleavage on pair of basic residues
|
|
gptkbp:recipient
|
gptkb:TNFRSF1A
gptkb:TNFRSF1B
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequence
|
233
|
|
gptkbp:structure
|
Homotrimer
|
|
gptkbp:subcellularLocation
|
gptkb:Cell_membrane
Secreted
|
|
gptkbp:targetOfDrug
|
gptkb:Adalimumab
gptkb:Etanercept
Certolizumab pegol
Golimumab
Infliximab
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:P05362
|
|
gptkbp:bfsLayer
|
8
|