Nutlin-3

GPTKB entity

Statements (34)
Predicate Object
gptkbp:instanceOf small molecule
imidazoline derivative
gptkbp:administeredBy in vitro studies
in vivo studies
gptkbp:bioactivity activates p53 pathway
gptkbp:CASNumber 548472-68-0
gptkbp:chemicalFormula C30H30Cl2N4O4
gptkbp:criteria selective for MDM2
gptkbp:developedBy gptkb:Hoffmann-La_Roche
gptkbp:discoveredBy Vassilev et al.
gptkbp:has_stereochemistry gptkb:Nutlin-3a
gptkb:Nutlin-3b
https://www.w3.org/2000/01/rdf-schema#label Nutlin-3
gptkbp:inducedBy cell cycle arrest
p53-dependent apoptosis
gptkbp:inhibitedBy MDM2-p53 interaction
gptkbp:IUPACName 4-[(4,5-dihydro-4,4,5,5-tetramethyl-1,3-imidazol-2-ylidene)amino]-2-(4-chlorophenyl)-2-oxo-N-(4-pyridinylmethyl)-1,3-thiazolidine-3-carboxamide
gptkbp:mechanismOfAction prevents MDM2 from binding to p53
gptkbp:molecularWeight 581.49 g/mol
gptkbp:PubChem_CID 9932206
CHEMBL1213108
gptkbp:relatedTo cell cycle regulation
cancer therapeutics
apoptosis modulation
gptkbp:synonym gptkb:Nutlin-3a
cis-Nutlin-3
gptkbp:target gptkb:MDM2
gptkbp:testedBy preclinical studies
gptkbp:UNII 6Z5F8O7E0Z
gptkbp:usedAs tool compound
gptkbp:usedIn cancer research
gptkbp:bfsParent gptkb:E3_ubiquitin-protein_ligase_Mdm2
gptkb:Mdm2
gptkbp:bfsLayer 7