Statements (34)
Predicate | Object |
---|---|
gptkbp:instanceOf |
small molecule
imidazoline derivative |
gptkbp:administeredBy |
in vitro studies
in vivo studies |
gptkbp:bioactivity |
activates p53 pathway
|
gptkbp:CASNumber |
548472-68-0
|
gptkbp:chemicalFormula |
C30H30Cl2N4O4
|
gptkbp:criteria |
selective for MDM2
|
gptkbp:developedBy |
gptkb:Hoffmann-La_Roche
|
gptkbp:discoveredBy |
Vassilev et al.
|
gptkbp:has_stereochemistry |
gptkb:Nutlin-3a
gptkb:Nutlin-3b |
https://www.w3.org/2000/01/rdf-schema#label |
Nutlin-3
|
gptkbp:inducedBy |
cell cycle arrest
p53-dependent apoptosis |
gptkbp:inhibitedBy |
MDM2-p53 interaction
|
gptkbp:IUPACName |
4-[(4,5-dihydro-4,4,5,5-tetramethyl-1,3-imidazol-2-ylidene)amino]-2-(4-chlorophenyl)-2-oxo-N-(4-pyridinylmethyl)-1,3-thiazolidine-3-carboxamide
|
gptkbp:mechanismOfAction |
prevents MDM2 from binding to p53
|
gptkbp:molecularWeight |
581.49 g/mol
|
gptkbp:PubChem_CID |
9932206
CHEMBL1213108 |
gptkbp:relatedTo |
cell cycle regulation
cancer therapeutics apoptosis modulation |
gptkbp:synonym |
gptkb:Nutlin-3a
cis-Nutlin-3 |
gptkbp:target |
gptkb:MDM2
|
gptkbp:testedBy |
preclinical studies
|
gptkbp:UNII |
6Z5F8O7E0Z
|
gptkbp:usedAs |
tool compound
|
gptkbp:usedIn |
cancer research
|
gptkbp:bfsParent |
gptkb:E3_ubiquitin-protein_ligase_Mdm2
gptkb:Mdm2 |
gptkbp:bfsLayer |
7
|