TIMP (tissue inhibitor of metalloproteinases)
GPTKB entity
Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
TIMP
|
| gptkbp:binds |
active site of MMPs
|
| gptkbp:discoveredBy |
1980s
|
| gptkbp:expressedIn |
many tissues
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
inhibits matrix metalloproteinases (MMPs)
|
| gptkbp:gene |
gptkb:TIMP1
gptkb:TIMP2 gptkb:TIMP3 gptkb:TIMP4 |
| https://www.w3.org/2000/01/rdf-schema#label |
TIMP (tissue inhibitor of metalloproteinases)
|
| gptkbp:involves |
apoptosis
cell proliferation angiogenesis tissue remodeling |
| gptkbp:member |
gptkb:TIMP1
gptkb:TIMP2 gptkb:TIMP3 gptkb:TIMP4 |
| gptkbp:molecularWeight |
~21 kDa (TIMP1)
~23 kDa (TIMP4) ~24 kDa (TIMP2) ~24 kDa (TIMP3) |
| gptkbp:regulates |
extracellular matrix remodeling
MMP activity |
| gptkbp:significance |
gptkb:cancer
gptkb:cardiovascular_disease fibrosis |
| gptkbp:structure |
contains N-terminal and C-terminal domains
|
| gptkbp:bfsParent |
gptkb:Matrix_metalloproteinase
|
| gptkbp:bfsLayer |
7
|