|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:STK4
|
|
gptkbp:associatedWith
|
gptkb:cancer
immune system regulation
|
|
gptkbp:discoveredBy
|
Yuan et al.
|
|
gptkbp:discoveredIn
|
2002
|
|
gptkbp:encodedBy
|
gptkb:STK4_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000104951
6789
|
|
gptkbp:function
|
serine/threonine kinase activity
|
|
gptkbp:gene
|
gptkb:STK4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MST-1
|
|
gptkbp:interactsWith
|
gptkb:FOXO1
gptkb:RASSF_family_proteins
gptkb:SAV1
gptkb:TAZ
MOB1
|
|
gptkbp:involvedIn
|
gptkb:Hippo_signaling_pathway
|
|
gptkbp:length
|
487 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
20q13.12
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
5B6J
|
|
gptkbp:phosphorylates
|
gptkb:FOXO3
gptkb:LATS1
gptkb:LATS2
gptkb:YAP1
|
|
gptkbp:postTranslationalModification
|
autophosphorylation
cleavage by caspase-3
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
cell migration
tissue homeostasis
cell death
activated by caspase cleavage
activated by oxidative stress
organ size
stem cell self-renewal
cell contact inhibition
inhibited by phosphorylation at Thr183
|
|
gptkbp:structure
|
contains kinase domain
contains SARAH domain
|
|
gptkbp:UniProtID
|
gptkb:Q13043
|
|
gptkbp:bfsParent
|
gptkb:MST1
gptkb:Forkhead_box_protein_O4
|
|
gptkbp:bfsLayer
|
8
|