|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:KPM
WARTS
LATS2_HUMAN
|
|
gptkbp:associatedWith
|
gptkb:cancer
mesothelioma
hepatocellular carcinoma
glioma
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:Entrez_Gene_ID
|
26524
ENSG00000104953
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:fullName
|
Large Tumor Suppressor Kinase 2
|
|
gptkbp:function
|
tumor suppressor
serine/threonine-protein kinase
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:6510
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LATS2
|
|
gptkbp:interactsWith
|
gptkb:LATS1
gptkb:SAV1
gptkb:TAZ
gptkb:YAP1
MOB1
|
|
gptkbp:involvedIn
|
gptkb:Hippo_signaling_pathway
|
|
gptkbp:length
|
1088 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
13q12.11
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
loss of function promotes tumorigenesis
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:phosphorylates
|
gptkb:TAZ
gptkb:YAP1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:MDM2
gptkb:p53
apoptosis
cell proliferation
cellular senescence
cell cycle
mitotic exit
spindle assembly checkpoint
centrosome duplication
|
|
gptkbp:UniProtID
|
Q9NRM7
|
|
gptkbp:bfsParent
|
gptkb:MST1
gptkb:LATS
gptkb:Hippo_signaling_pathway
gptkb:MST2
gptkb:YAP1
|
|
gptkbp:bfsLayer
|
8
|