|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:YAP
YAP65
Yes-associated protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:glioblastoma
colorectal cancer
hepatocellular carcinoma
|
|
gptkbp:discoveredBy
|
Sudol et al.
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:domain
|
gptkb:WW_domain
transcriptional activation domain
TEAD-binding domain
|
|
gptkbp:encodedBy
|
YAP1 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000137693
|
|
gptkbp:expressedIn
|
widely expressed
|
|
gptkbp:fullName
|
Yes-associated protein 1
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
transcriptional co-activator
|
|
gptkbp:gene
|
gptkb:YAP1
|
|
gptkbp:HGNC_ID
|
16262
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
YAP1
|
|
gptkbp:inhibitedBy
|
verteporfin
|
|
gptkbp:interactsWith
|
TEAD1
TEAD2
TEAD3
TEAD4
|
|
gptkbp:involvedIn
|
gptkb:Hippo_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
11q22
|
|
gptkbp:molecularWeight
|
65 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
Drosophila melanogaster (yorkie)
|
|
gptkbp:phosphorylates
|
gptkb:LATS1
gptkb:LATS2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:RefSeq
|
NM_006106
|
|
gptkbp:regulates
|
cell growth
organ size
stem cell self-renewal
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P46937
|
|
gptkbp:bfsParent
|
gptkb:PTPN14
|
|
gptkbp:bfsLayer
|
7
|