|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:WTS
WARTS
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:discoveredBy
|
Harvey et al.
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:encodedBy
|
LATS1 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000106689
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
Large tumor suppressor kinase 1
|
|
gptkbp:function
|
tumor suppressor
serine/threonine-protein kinase
|
|
gptkbp:gene
|
gptkb:LATS1
|
|
gptkbp:GOID
|
gptkb:GO:0004674
GO:0005634
GO:0005737
GO:0004712
|
|
gptkbp:HGNC_ID
|
HGNC:6512
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LATS1
|
|
gptkbp:interactsWith
|
gptkb:SAV1
gptkb:TAZ
gptkb:YAP1
MOB1
|
|
gptkbp:involvedIn
|
gptkb:Hippo_signaling_pathway
|
|
gptkbp:length
|
1130
|
|
gptkbp:locatedOnChromosome
|
10q21.3
|
|
gptkbp:molecularWeight
|
127 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
increased cell proliferation
tumor formation
|
|
gptkbp:OMIM
|
603473
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
KEGG:hsa04390
Reactome:R-HSA-2028269
|
|
gptkbp:PDB
|
6O5J
|
|
gptkbp:phosphorylates
|
gptkb:TAZ
gptkb:YAP1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
|
|
gptkbp:significance
|
tumor suppressor
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
O95835
|
|
gptkbp:bfsParent
|
gptkb:MST1
gptkb:NF2
gptkb:human_chromosome_6q25
gptkb:LATS
gptkb:Hippo_signaling_pathway
gptkb:MST2
gptkb:YAP1
gptkb:ITCHY_E3_ubiquitin_protein_ligase
gptkb:ITCH_protein
gptkb:MAGI3_protein
gptkb:6q25.2
|
|
gptkbp:bfsLayer
|
8
|