|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:KRS2
gptkb:KRS2_kinase
gptkb:MST-1
gptkb:STK4
gptkb:Serine/threonine-protein_kinase_4
|
|
gptkbp:cleavage
|
active kinase fragment
|
|
gptkbp:discoveredBy
|
researchers in the late 1990s
|
|
gptkbp:encodedBy
|
gptkb:STK4_gene
|
|
gptkbp:Entrez_Gene_ID
|
6789
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Mammalian_STE20-like_protein_kinase_1
|
|
gptkbp:function
|
serine/threonine-protein kinase
|
|
gptkbp:gene
|
gptkb:STK4
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11408
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MST1
|
|
gptkbp:interactsWith
|
gptkb:RASSF_family_proteins
gptkb:SAV1
|
|
gptkbp:involvedIn
|
gptkb:Hippo_signaling_pathway
apoptosis
cell proliferation regulation
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xq28
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
56 kDa
|
|
gptkbp:mutationAssociatedWith
|
immunodeficiency 47
|
|
gptkbp:OMIM
|
604965
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Stk4
|
|
gptkbp:orthologInYeast
|
gptkb:Ste20
|
|
gptkbp:PDB
|
gptkb:5B6K
5B6J
5B6L
|
|
gptkbp:phosphorylates
|
gptkb:FOXO3
gptkb:LATS1
gptkb:LATS2
gptkb:YAP1
|
|
gptkbp:postTranslationalModification
|
autophosphorylation
cleavage by caspases
|
|
gptkbp:regulates
|
regulated by phosphorylation
tissue homeostasis
cell death
activated by caspase cleavage
activated by oxidative stress
organ size
|
|
gptkbp:structure
|
contains kinase domain
contains SARAH domain
|
|
gptkbp:UniProtID
|
gptkb:Q13043
|
|
gptkbp:bfsParent
|
gptkb:RASSF5
gptkb:RASSF_proteins
gptkb:chromosome_1q32
gptkb:RASSF1
gptkb:RASSF2
gptkb:RASSF6
|
|
gptkbp:bfsLayer
|
7
|