major histocompatibility complex class I

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:MHC_class_I
gptkbp:component	gptkb:beta-2_microglobulin alpha chain
gptkbp:discoveredBy	gptkb:Jean_Dausset
gptkbp:discoveredIn	1958
gptkbp:encodedBy	MHC gene cluster
gptkbp:foundIn	all nucleated cells of jawed vertebrates
gptkbp:function	presentation of peptide antigens to cytotoxic T cells
gptkbp:gene	gptkb:HLA-A gptkb:HLA-B gptkb:HLA-C
https://www.w3.org/2000/01/rdf-schema#label	major histocompatibility complex class I
gptkbp:locatedOnChromosome	gptkb:chromosome_6_(human)
gptkbp:mouseGene	gptkb:H-2D gptkb:H-2K gptkb:H-2L
gptkbp:presentAntigenFrom	endogenous proteins
gptkbp:recognizedBy	gptkb:CD8+_T_cells natural killer cells (absence or downregulation)
gptkbp:relatedTo	gptkb:HLA_system gptkb:proteasome gptkb:TAP_transporter immunology antigen processing major histocompatibility complex class II major histocompatibility complex class III
gptkbp:roleInImmunity	immune surveillance viral infection response self/non-self discrimination tumor cell recognition
gptkbp:significance	organ transplantation immunotherapy autoimmune diseases immunodeficiency
gptkbp:species	gptkb:human gptkb:mouse
gptkbp:structure	transmembrane glycoprotein
gptkbp:bfsParent	gptkb:MHC_class_I_molecules
gptkbp:bfsLayer	7