|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alphaChainEncodedBy
|
gptkb:HLA-A
gptkb:HLA-B
gptkb:HLA-C
|
|
gptkbp:alternativeName
|
gptkb:H-2_class_I_(in_mice)
gptkb:HLA_class_I_(in_humans)
|
|
gptkbp:antigenProcessingPathway
|
endogenous pathway
|
|
gptkbp:beta2MicroglobulinEncodedBy
|
B2M gene
|
|
gptkbp:discoveredBy
|
gptkb:Jean_Dausset
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
MHC gene cluster
|
|
gptkbp:foundIn
|
all nucleated cells of jawed vertebrates
|
|
gptkbp:fullName
|
Major Histocompatibility Complex class I
|
|
gptkbp:function
|
presentation of peptide antigens to cytotoxic T cells
|
|
gptkbp:hasPolymorphism
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MHC I
|
|
gptkbp:interactsWith
|
cell surface receptor
CD8 co-receptor
|
|
gptkbp:location
|
cell surface
|
|
gptkbp:peptideLoading
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:peptideSource
|
cytosolic proteins
|
|
gptkbp:presentedPeptidesLength
|
8-10 amino acids
|
|
gptkbp:recognizedBy
|
gptkb:CD8+_T_cells
|
|
gptkbp:roleInImmunity
|
detection of intracellular pathogens
|
|
gptkbp:roleInTransplantation
|
major determinant of graft rejection
|
|
gptkbp:significance
|
infectious diseases
organ transplantation
immunotherapy
autoimmune diseases
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
other jawed vertebrates
|
|
gptkbp:structure
|
heterodimer of alpha chain and beta-2 microglobulin
|
|
gptkbp:bfsParent
|
gptkb:MHC_class_I_molecules
|
|
gptkbp:bfsLayer
|
7
|