|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:LEF1
|
|
gptkbp:binds
|
gptkb:gene
|
|
gptkbp:discoveredBy
|
gptkb:Ueli_Schibler
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000138795
|
|
gptkbp:expressedIn
|
gptkb:thymus
lymphoid tissues
pre-B and T cells
|
|
gptkbp:foundIn
|
gptkb:nucleus
|
|
gptkbp:fullName
|
gptkb:Lymphoid_Enhancer-binding_Factor
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:HGNC_ID
|
6551
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LEF
|
|
gptkbp:interactsWith
|
gptkb:CBP/p300
gptkb:beta-catenin
gptkb:Groucho
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
4q25 (human)
|
|
gptkbp:mutationAssociatedWith
|
leukemia
chronic lymphocytic leukemia
|
|
gptkbp:OMIM
|
153245
|
|
gptkbp:orthologIn
|
gptkb:Dragon
gptkb:meat
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:TCF/LEF_family
|
|
gptkbp:regulates
|
gptkb:CD4_gene
gptkb:IL2_gene
gptkb:LEF1_gene
gptkb:MMP7_gene
gptkb:TCF7_gene
gene expression
Wnt target genes
Axin2 gene
Cyclin D1 gene
c-myc gene
|
|
gptkbp:relatedTo
|
gptkb:TCF7
gptkb:TCF7L1
gptkb:TCF7L2
|
|
gptkbp:role
|
T cell development
B cell development
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
contains HMG-box domain
|
|
gptkbp:UniProtID
|
Q9UJU2
|
|
gptkbp:bfsParent
|
gptkb:Innovus
|
|
gptkbp:bfsLayer
|
6
|