|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
hematopoiesis
T-cell development
hair follicle development
|
|
gptkbp:discoveredBy
|
gptkb:Ueli_Schibler
|
|
gptkbp:encodes
|
LEF1 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000138795
51176
|
|
gptkbp:expressedIn
|
gptkb:thymus
lymphoid tissues
hair follicles
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:fullName
|
Lymphoid enhancer-binding factor 1
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
transcription factor
|
|
gptkbp:HGNC_ID
|
6551
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
LEF1 gene
|
|
gptkbp:interactsWith
|
gptkb:TCF7
Groucho/TLE proteins
CTNNB1 (beta-catenin)
|
|
gptkbp:locatedOnChromosome
|
4
4q25
|
|
gptkbp:mutationAssociatedWith
|
leukemia
chronic lymphocytic leukemia
|
|
gptkbp:OMIM
|
153245
|
|
gptkbp:orthologInMouse
|
Lef1
|
|
gptkbp:proteinFamily
|
gptkb:TCF/LEF_family
|
|
gptkbp:regulates
|
gptkb:beta-catenin
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
Q9UJU2
|
|
gptkbp:bfsParent
|
gptkb:LEF
|
|
gptkbp:bfsLayer
|
7
|