Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
cytokine |
| gptkbp:alternativeName |
IL-1Ra
interleukin-1 receptor antagonist |
| gptkbp:approvedDrugName |
gptkb:anakinra
|
| gptkbp:discoveredBy |
Charles A. Dinarello
|
| gptkbp:encodedBy |
IL1RN gene
|
| gptkbp:expressedIn |
gptkb:kidney
liver adipose tissue macrophages monocytes epithelial cells neutrophils |
| gptkbp:firstDescribed |
1990
|
| gptkbp:foundIn |
humans
mice other mammals |
| gptkbp:function |
blocks activity of interleukin-1 alpha
blocks activity of interleukin-1 beta |
| gptkbp:hasTherapeuticUse |
rheumatoid arthritis
auto-inflammatory diseases |
| gptkbp:HGNC_ID |
HGNC:5993
|
| https://www.w3.org/2000/01/rdf-schema#label |
IL-1 receptor antagonist
|
| gptkbp:inhibitedBy |
interleukin-1 receptor
|
| gptkbp:locatedOnChromosome |
chromosome 2q14.2 (human)
|
| gptkbp:mechanismOfAction |
competitive inhibitor of IL-1 binding
|
| gptkbp:molecularWeight |
17 kDa
|
| gptkbp:structure |
single-chain glycoprotein
|
| gptkbp:UniProtID |
P18510
|
| gptkbp:usedAs |
gptkb:drug
|
| gptkbp:bfsParent |
gptkb:IL-1
|
| gptkbp:bfsLayer |
7
|