|
gptkbp:instanceOf
|
gptkb:cytokine
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:interleukin-1_receptor_antagonist
IL-1Ra
|
|
gptkbp:approvedDrugName
|
gptkb:anakinra
|
|
gptkbp:discoveredBy
|
Charles A. Dinarello
|
|
gptkbp:encodedBy
|
IL1RN gene
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
gptkb:kidney
liver
macrophages
monocytes
epithelial cells
neutrophils
|
|
gptkbp:firstDescribed
|
1990
|
|
gptkbp:foundIn
|
humans
mice
other mammals
|
|
gptkbp:function
|
blocks activity of interleukin-1 alpha
blocks activity of interleukin-1 beta
|
|
gptkbp:hasTherapeuticUse
|
rheumatoid arthritis
auto-inflammatory diseases
|
|
gptkbp:HGNC_ID
|
HGNC:5993
|
|
gptkbp:inhibitedBy
|
interleukin-1 receptor
|
|
gptkbp:locatedOnChromosome
|
chromosome 2q14.2 (human)
|
|
gptkbp:mechanismOfAction
|
competitive inhibitor of IL-1 binding
|
|
gptkbp:molecularWeight
|
17 kDa
|
|
gptkbp:structure
|
single-chain glycoprotein
|
|
gptkbp:UniProtID
|
P18510
|
|
gptkbp:usedAs
|
gptkb:drug
|
|
gptkbp:bfsParent
|
gptkb:IL-1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL-1 receptor antagonist
|