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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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Atrophin-1-interacting protein 4
E3 ubiquitin-protein ligase Itchy homolog
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gptkbp:associatedWith
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immunodeficiency
autoimmune disease
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gptkbp:biologicalProcess
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cell signaling
immune response
regulation of transcription
protein ubiquitination
protein catabolic process
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gptkbp:discoveredBy
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researchers studying mouse mutant 'itchy' phenotype
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gptkbp:domain
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gptkb:WW_domain
gptkb:HECT_domain
proline-rich region
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gptkbp:encodedBy
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ITCH gene
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gptkbp:Entrez_Gene_ID
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83737
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gptkbp:function
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gptkb:E3_ubiquitin-protein_ligase
ubiquitin-mediated protein degradation
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https://www.w3.org/2000/01/rdf-schema#label
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ITCH protein
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gptkbp:interactsWith
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gptkb:p63
gptkb:p73
gptkb:c-Jun
gptkb:c-FLIP
gptkb:LATS1
gptkb:SMURF1
gptkb:WWP1
gptkb:Notch1
transcription factors
NEDD4 family proteins
p45/NF-E2
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gptkbp:locatedOnChromosome
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20q11.22
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
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~100 kDa
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gptkbp:mutationAssociatedWith
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autosomal recessive syndromic multisystem autoimmune disease
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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gptkb:Mus_musculus
gptkb:Rattus_norvegicus
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gptkbp:postTranslationalModification
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phosphorylation
ubiquitination
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gptkbp:regulates
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gptkb:Notch_signaling_pathway
gptkb:LATS1_protein
transcription factors
c-Jun protein
Jun pathway
c-FLIP protein
p45/NF-E2 protein
p63 protein
p73 protein
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gptkbp:UniProtID
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Q96J02
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gptkbp:bfsParent
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gptkb:WW_domain
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gptkbp:bfsLayer
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7
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