|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:NOTCH
hN1
Tan1
|
|
gptkbp:associatedWith
|
gptkb:Alagille_syndrome
gptkb:T-cell_acute_lymphoblastic_leukemia
|
|
gptkbp:domain
|
transmembrane domain
EGF-like domain
ankyrin repeat domain
|
|
gptkbp:encodes
|
Notch1 protein
|
|
gptkbp:Entrez_Gene_ID
|
4851
ENSG00000148400
|
|
gptkbp:entrezGene
|
4851
|
|
gptkbp:expressedIn
|
hematopoietic cells
embryonic tissues
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
signal transduction
cell fate determination
|
|
gptkbp:HGNC_ID
|
7881
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Notch1
|
|
gptkbp:interactsWith
|
gptkb:RBPJ
gptkb:Jagged1
Delta-like ligand 1 (DLL1)
|
|
gptkbp:involvedIn
|
gptkb:Notch_signaling_pathway
|
|
gptkbp:length
|
2555
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_2_(mouse)
gptkb:chromosome_9_(human)
|
|
gptkbp:molecularWeight
|
~272 kDa
|
|
gptkbp:mutationAssociatedWith
|
cancer predisposition
developmental defects
|
|
gptkbp:OMIM
|
190198
|
|
gptkbp:orthologIn
|
Drosophila Notch
mouse Notch1
zebrafish notch1a
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:proteinFamily
|
gptkb:Notch_family
|
|
gptkbp:reviewedBy
|
gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProt
gptkb:Ensembl
|
|
gptkbp:subcellularLocation
|
gptkb:plasma_membrane
nucleus (after cleavage)
|
|
gptkbp:UniProtID
|
P46531
|
|
gptkbp:bfsParent
|
gptkb:human_NOTCH1_gene
gptkb:NOTCH1
|
|
gptkbp:bfsLayer
|
7
|