|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD126
IL6RA
|
|
gptkbp:associatedWith
|
gptkb:Castleman_disease
rheumatoid arthritis
COVID-19 cytokine storm
|
|
gptkbp:component
|
IL-6 receptor complex
|
|
gptkbp:discoveredBy
|
gptkb:Tadamitsu_Kishimoto
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodedBy
|
gptkb:IL6R_gene
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
gptkb:B_cells
gptkb:T_cells
macrophages
immune cells
neutrophils
|
|
gptkbp:fullName
|
Interleukin-6 receptor
|
|
gptkbp:function
|
binds interleukin-6
mediates IL-6 signaling
|
|
gptkbp:gene
|
gptkb:IL6R
|
|
gptkbp:hasPolymorphism
|
Asp358Ala
|
|
gptkbp:HGNC_ID
|
6019
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IL-6R
|
|
gptkbp:involvedIn
|
gptkb:JAK/STAT_signaling_pathway
inflammation
immune response
|
|
gptkbp:isSolubleIn
|
sIL-6R
|
|
gptkbp:locatedOnChromosome
|
1q21
|
|
gptkbp:location
|
gptkb:cell_membrane
extracellular region
|
|
gptkbp:molecularWeight
|
80 kDa
|
|
gptkbp:OMIM
|
147880
|
|
gptkbp:PDB
|
1N26
|
|
gptkbp:subunit
|
gptkb:gp130
IL-6R alpha chain
|
|
gptkbp:target
|
gptkb:tocilizumab
gptkb:sarilumab
|
|
gptkbp:UniProtID
|
P08887
|
|
gptkbp:bfsParent
|
gptkb:interleukin-6_receptor
gptkb:IL6_gene
|
|
gptkbp:bfsLayer
|
7
|