|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:IGF-I
Somatomedin C
IGF1A
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Laron_syndrome
growth hormone insensitivity
|
|
gptkbp:biologicalProcess
|
cell survival
glucose metabolism
growth factor activity
muscle development
skeletal development
|
|
gptkbp:clinicalTrialPhase
|
serum IGF-1 measurement
|
|
gptkbp:discoveredBy
|
D.R. Clemmons
|
|
gptkbp:discoveredIn
|
1978
|
|
gptkbp:encodes
|
gptkb:insulin-like_growth_factor_1
|
|
gptkbp:Entrez_Gene_ID
|
3479
ENSG00000017427
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:skeletal_muscle
liver
collagen
|
|
gptkbp:function
|
cell differentiation
cell proliferation
metabolic regulation
regulation of growth
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5464
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF1 gene
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q23.2
|
|
gptkbp:mutationAssociatedWith
|
insulin resistance
delayed puberty
growth retardation
|
|
gptkbp:OMIM
|
147440
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Igf1
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:product
|
gptkb:IGF-1
|
|
gptkbp:recipient
|
gptkb:insulin_receptor
gptkb:IGF1R
|
|
gptkbp:regulates
|
gptkb:insulin
recombinant human growth hormone
nutritional status
|
|
gptkbp:UniProtID
|
P05019
|
|
gptkbp:bfsParent
|
gptkb:Insulin-like_Growth_Factor
|
|
gptkbp:bfsLayer
|
7
|