|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:INDO
gptkb:Indoleamine-pyrrole_2,3-dioxygenase
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
immune response regulation
oxidoreductase activity
tryptophan catabolic process
|
|
gptkbp:cofactor
|
hemoglobin
|
|
gptkbp:encodedBy
|
gptkb:IDO1_gene
|
|
gptkbp:Entrez_Gene_ID
|
3620
ENSG00000131203
|
|
gptkbp:enzymeCommissionNumber
|
1.13.11.52
|
|
gptkbp:expressedIn
|
gptkb:placenta
dendritic cells
macrophages
|
|
gptkbp:fullName
|
gptkb:Indoleamine_2,3-dioxygenase_1
|
|
gptkbp:function
|
catalyzes the first step in tryptophan catabolism via the kynurenine pathway
|
|
gptkbp:gene
|
gptkb:IDO1
|
|
gptkbp:GO
|
GO:0004517
|
|
gptkbp:HGNC_ID
|
gptkb:Indoleamine_2,3-dioxygenase_1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IDO1
|
|
gptkbp:inducedBy
|
gptkb:interferon-gamma
|
|
gptkbp:inhibitedBy
|
gptkb:epacadostat
gptkb:indoximod
gptkb:navoximod
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p11.21
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:OMIM
|
147780
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:Kynurenine_pathway
gptkb:Tryptophan_metabolism
|
|
gptkbp:PDB
|
gptkb:2D0T
4PK5
5WN8
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:product
|
N-formylkynurenine
|
|
gptkbp:RefSeq
|
NP_002159
|
|
gptkbp:regulates
|
T cell proliferation
immune tolerance
|
|
gptkbp:structure
|
monomer
|
|
gptkbp:substrate
|
L-tryptophan
|
|
gptkbp:UniProtID
|
P14902
|
|
gptkbp:bfsParent
|
gptkb:IDO
|
|
gptkbp:bfsLayer
|
6
|