|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:INDO
gptkb:IDO
gptkb:INDO1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
autoimmune diseases
chronic inflammation
cancer immune evasion
|
|
gptkbp:biologicalProcess
|
immune response regulation
oxidoreductase activity
tryptophan catabolic process
|
|
gptkbp:clinicalTrialPhase
|
immunotherapy
|
|
gptkbp:discoveredBy
|
gptkb:Yoshida_et_al.
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodes
|
indoleamine 2,3-dioxygenase 1 protein
|
|
gptkbp:Entrez_Gene_ID
|
3620
ENSG00000131203
|
|
gptkbp:expressedIn
|
gptkb:placenta
dendritic cells
macrophages
tumor cells
|
|
gptkbp:fullName
|
gptkb:indoleamine_2,3-dioxygenase_1
|
|
gptkbp:function
|
catalyzes the first step in tryptophan catabolism via the kynurenine pathway
|
|
gptkbp:HGNC_ID
|
HGNC:6059
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IDO1 gene
|
|
gptkbp:inducedBy
|
gptkb:interferon-gamma
|
|
gptkbp:inhibitedBy
|
gptkb:epacadostat
1-methyl-tryptophan
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p11.21
chromosome 8
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ido1
|
|
gptkbp:proteinFamily
|
gptkb:indoleamine_2,3-dioxygenase_family
|
|
gptkbp:UniProtID
|
P14902
|
|
gptkbp:bfsParent
|
gptkb:IDO1
|
|
gptkbp:bfsLayer
|
7
|