Indoleamine-pyrrole 2,3-dioxygenase
GPTKB entity
Statements (26)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:IDO
gptkb:indoleamine_2,3-dioxygenase |
| gptkbp:catalyzes |
oxidation of tryptophan to N-formylkynurenine
|
| gptkbp:cofactor |
hemoglobin
|
| gptkbp:EC_number |
1.13.11.42
|
| gptkbp:expressedIn |
gptkb:placenta
dendritic cells macrophages |
| gptkbp:foundIn |
humans
mammals |
| gptkbp:gene |
gptkb:IDO1
|
| https://www.w3.org/2000/01/rdf-schema#label |
Indoleamine-pyrrole 2,3-dioxygenase
|
| gptkbp:inducedBy |
gptkb:interferon-gamma
|
| gptkbp:inhibitedBy |
1-methyl-tryptophan
can suppress T cell function |
| gptkbp:involves |
immune regulation
tryptophan catabolism |
| gptkbp:locatedOnChromosome |
8p11.21 (human)
|
| gptkbp:role |
autoimmune disorders
chronic inflammation cancer immune evasion |
| gptkbp:structure |
monomeric protein
|
| gptkbp:UniProtID |
P14902
|
| gptkbp:bfsParent |
gptkb:IDO1
|
| gptkbp:bfsLayer |
7
|