Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:discoveredBy |
gptkb:Albert_Szent-Györgyi
|
| gptkbp:enzyme |
gptkb:kynureninase
gptkb:indoleamine_2,3-dioxygenase_(IDO) gptkb:kynurenine_aminotransferase_(KAT) gptkb:kynurenine_monooxygenase_(KMO) gptkb:tryptophan_2,3-dioxygenase_(TDO) |
| gptkbp:firstDescribed |
1930s
|
| https://www.w3.org/2000/01/rdf-schema#label |
Kynurenine pathway
|
| gptkbp:involves |
gptkb:tryptophan_metabolism
|
| gptkbp:location |
brain
liver immune cells |
| gptkbp:produces |
gptkb:3-hydroxykynurenine
gptkb:kynurenic_acid gptkb:kynurenine gptkb:nicotinamide_adenine_dinucleotide_(NAD+) gptkb:quinolinic_acid anthranilic acid |
| gptkbp:regulates |
NAD+ biosynthesis
|
| gptkbp:relatedTo |
gptkb:cancer
gptkb:depression neurodegenerative diseases immune regulation |
| gptkbp:substrate |
tryptophan
|
| gptkbp:bfsParent |
gptkb:IDO1
|
| gptkbp:bfsLayer |
7
|