Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:indoleamine-pyrrole_2,3-dioxygenase
tryptophan 2,3-dioxygenase (TDO) (not to be confused) |
| gptkbp:cofactor |
hemoglobin
|
| gptkbp:discoveredBy |
gptkb:Hayaishi_Osamu
|
| gptkbp:discoveredIn |
1967
|
| gptkbp:EC_number |
1.13.11.52
|
| gptkbp:expressedIn |
gptkb:placenta
dendritic cells macrophages |
| gptkbp:fullName |
gptkb:indoleamine_2,3-dioxygenase
|
| gptkbp:function |
catalyzes the first step in tryptophan catabolism
|
| gptkbp:gene |
gptkb:IDO1
gptkb:IDO2 |
| https://www.w3.org/2000/01/rdf-schema#label |
IDO
|
| gptkbp:inhibitedBy |
1-methyl-tryptophan
|
| gptkbp:locatedOnChromosome |
8p11.21 (IDO1 gene in humans)
|
| gptkbp:location |
cytosol
|
| gptkbp:molecularWeight |
45 kDa
|
| gptkbp:organism |
gptkb:human
gptkb:mouse |
| gptkbp:PDB |
gptkb:2D0T
|
| gptkbp:product |
N-formylkynurenine
|
| gptkbp:role |
cancer immunosuppression
immune regulation |
| gptkbp:substrate |
tryptophan
|
| gptkbp:UniProtID |
P14902
|
| gptkbp:bfsParent |
gptkb:Bosphorus
gptkb:KDDI |
| gptkbp:bfsLayer |
5
|