|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Heat_shock_cognate_71_kDa_protein
|
|
gptkbp:discoveredBy
|
J. Ellis
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:enzymeClassification
|
EC 3.6.4.10
|
|
gptkbp:expressedIn
|
all tissues
|
|
gptkbp:family
|
gptkb:Hsp70_family
|
|
gptkbp:function
|
molecular chaperone
|
|
gptkbp:gene
|
gptkb:HSPA8
|
|
gptkbp:GO_term
|
GO:0005737
GO:0005524
GO:0006457
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hsc70
|
|
gptkbp:interactsWith
|
gptkb:CHIP
gptkb:BAG1
gptkb:Hsp40
gptkb:Hsp90
DNAJ proteins
|
|
gptkbp:involvedIn
|
protein folding
protein transport
prevention of protein aggregation
|
|
gptkbp:locatedOnChromosome
|
chromosome 6q23.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
71 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Hsc70
rat Hsc70
yeast Ssa1
|
|
gptkbp:PDB
|
gptkb:3ATX
1YUW
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
protein degradation
autophagy
endocytosis
|
|
gptkbp:relatedTo
|
gptkb:GRP78
gptkb:Hsp70
gptkb:Hsp90
|
|
gptkbp:requires
|
cell survival
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:virus
neurodegenerative diseases
|
|
gptkbp:structure
|
C-terminal domain
ATPase domain
substrate-binding domain
|
|
gptkbp:UniProtID
|
P11142
|
|
gptkbp:bfsParent
|
gptkb:clathrin
gptkb:Hsp70
|
|
gptkbp:bfsLayer
|
7
|