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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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gptkb:Hsp70
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gptkbp:associatedWith
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gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease
gptkb:cancer
gptkb:virus
neurodegenerative diseases
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gptkbp:discoveredBy
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gptkb:Ferruccio_Ritossa
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gptkbp:discoveredIn
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1962
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gptkbp:domain
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ATPase domain
substrate-binding domain
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gptkbp:foundIn
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gptkb:Bacteria
archaea
eukaryotes
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gptkbp:function
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protein folding
molecular chaperone
prevention of protein aggregation
assists in protein refolding
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gptkbp:GO
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gptkb:GO:0006457_(protein_folding)
gptkb:GO:0034605_(cellular_response_to_heat)
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https://www.w3.org/2000/01/rdf-schema#label
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Heat shock protein 70
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gptkbp:inducedBy
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heat shock
cellular stress
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gptkbp:interactsWith
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gptkb:Bag1
gptkb:Hsp40
co-chaperones
nucleotide exchange factors
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gptkbp:involvedIn
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immune response
apoptosis regulation
cellular stress response
antigen presentation
protein translocation
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gptkbp:locale
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gptkb:endoplasmic_reticulum
gptkb:nucleus
mitochondria
cytosol
extracellular space
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gptkbp:medicalUse
|
potential therapeutic target
biomarker for cellular stress
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gptkbp:memberOf
|
heat shock protein family
|
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gptkbp:molecularWeight
|
70 kDa
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gptkbp:orthologIn
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gptkb:HSPA12A
gptkb:HSPA12B
gptkb:HSPA13
gptkb:HSPA14
gptkb:HSPA1L
gptkb:HSPA2
gptkb:HSPA4
gptkb:HSPA4L
gptkb:HSPA6
gptkb:HSPA7
gptkb:HSPA9
gptkb:Hsc70
gptkb:HSPA1A
gptkb:HSPA1B
gptkb:HSPA8
gptkb:HSPA5
BiP (in endoplasmic reticulum)
DnaK (in E. coli)
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gptkbp:PDB
|
4B9Q
|
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gptkbp:proteinFamily
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gptkb:HSPA
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gptkbp:regulates
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post-translational modifications
protein homeostasis
transcriptional upregulation by heat shock factor 1 (HSF1)
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gptkbp:structure
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C-terminal substrate-binding domain
N-terminal ATPase domain
two-domain structure
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gptkbp:UniProtID
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gptkb:P0DMV8
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gptkbp:bfsParent
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gptkb:HSP70
gptkb:Hsp70
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gptkbp:bfsLayer
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7
|