Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:compatibleWith |
prokaryotes
|
| gptkbp:composedOf |
heavy chain
light chain |
| gptkbp:depolymerizedBy |
Hsc70 and auxilin
|
| gptkbp:discoveredBy |
gptkb:Barbara_Pearse
|
| gptkbp:discoveredIn |
1975
|
| gptkbp:encodedBy |
CLTC gene
CLTCL1 gene |
| gptkbp:form |
clathrin-coated vesicles
polyhedral lattice triskelion structure |
| gptkbp:foundIn |
eukaryotic cells
|
| gptkbp:function |
vesicle formation
|
| gptkbp:gene |
CLTC
CLTCL1 |
| gptkbp:GO |
GO:0006897 (endocytosis)
GO:0030136 (clathrin-coated vesicle) |
| https://www.w3.org/2000/01/rdf-schema#label |
clathrin
|
| gptkbp:interactsWith |
gptkb:Hsc70
gptkb:dynamin AP2 adaptor complex auxilin |
| gptkbp:involvedIn |
endocytosis
intracellular trafficking |
| gptkbp:locale |
gptkb:Golgi_apparatus
gptkb:plasma_membrane endosomes |
| gptkbp:molecularWeight |
~190 kDa (heavy chain)
~25-30 kDa (light chain) |
| gptkbp:OMIM |
118955
|
| gptkbp:PDB |
1XI4
|
| gptkbp:presentIn |
gptkb:protists
animals fungi plants |
| gptkbp:regulates |
membrane curvature
|
| gptkbp:relatedTo |
receptor-mediated endocytosis
synaptic vesicle recycling low-density lipoprotein (LDL) uptake transferrin uptake |
| gptkbp:role |
cargo selection
vesicle budding vesicle uncoating |
| gptkbp:structure |
three-legged triskelion
|
| gptkbp:subunit |
gptkb:clathrin_heavy_chain
clathrin light chain |
| gptkbp:UniProtID |
Q00610
Q00611 |
| gptkbp:visualizes |
electron microscopy
|
| gptkbp:bfsParent |
gptkb:PI3K-C2α
|
| gptkbp:bfsLayer |
6
|