Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Heat shock protein 70 family
|
| gptkbp:cofactor |
Hsp40 (DnaJ family)
nucleotide exchange factors (NEFs) |
| gptkbp:domain |
C-terminal domain
N-terminal ATPase domain substrate-binding domain |
| gptkbp:evolutionaryConservation |
highly conserved across species
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
protein folding
assists in protein transport across membranes molecular chaperone prevention of protein aggregation |
| gptkbp:GO_term |
protein folding
response to stress chaperone-mediated protein transport |
| https://www.w3.org/2000/01/rdf-schema#label |
Hsp70 family
|
| gptkbp:inducedBy |
heat shock
cellular stress |
| gptkbp:inhibitedBy |
gptkb:VER-155008
MKT-077 |
| gptkbp:KEGGID |
hsa:3306 (HSPA1A)
|
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:nucleus mitochondria cytosol chloroplast (in plants) |
| gptkbp:member |
gptkb:HSPA12A
gptkb:HSPA12B gptkb:HSPA13 gptkb:HSPA14 gptkb:HSPA1L gptkb:HSPA2 gptkb:HSPA4 gptkb:HSPA4L gptkb:HSPA6 gptkb:HSPA7 gptkb:HSPA9 gptkb:HSPA1A gptkb:HSPA1B gptkb:HSPA8 gptkb:HSPA5 DnaK (bacterial homolog) HSPA9B |
| gptkbp:molecularWeight |
approximately 70 kDa
|
| gptkbp:PDB |
4B9Q
|
| gptkbp:regulates |
transcriptionally regulated by heat shock factor 1 (HSF1)
|
| gptkbp:role |
gptkb:cancer
infectious diseases neurodegenerative diseases |
| gptkbp:structure |
conserved ATPase domain
conserved substrate-binding domain |
| gptkbp:UniProtID |
P0DMV8 (HSPA1A)
|
| gptkbp:bfsParent |
gptkb:Ssa2
gptkb:heat_shock_protein_70_family |
| gptkbp:bfsLayer |
7
|