|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Heat_shock_protein_70
|
|
gptkbp:domain
|
ATPase domain
substrate-binding domain
|
|
gptkbp:EC_number
|
3.6.4.10
|
|
gptkbp:expressedIn
|
all domains of life
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:function
|
protein folding
molecular chaperone
prevention of protein aggregation
|
|
gptkbp:GO
|
gptkb:GO:0006457_(protein_folding)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Hsp70
|
|
gptkbp:inducedBy
|
heat shock
cellular stress
|
|
gptkbp:inhibitedBy
|
gptkb:PES
gptkb:VER-155008
|
|
gptkbp:interactsWith
|
gptkb:Hsp40
co-chaperones
nucleotide exchange factors
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
chloroplasts
mitochondria
cytosol
|
|
gptkbp:memberOf
|
heat shock protein family
|
|
gptkbp:molecularWeight
|
approximately 70 kDa
|
|
gptkbp:orthologIn
|
gptkb:Hsc70
BiP (in endoplasmic reticulum)
DnaK (in E. coli)
|
|
gptkbp:PDB
|
4B9Q
|
|
gptkbp:postTranslationalModification
|
phosphorylation
acetylation
|
|
gptkbp:proteinFamily
|
gptkb:HSPA
|
|
gptkbp:regulates
|
gptkb:heat_shock_factor_1_(HSF1)
|
|
gptkbp:requires
|
cell survival under stress
|
|
gptkbp:role
|
immune response
protein degradation
apoptosis regulation
cellular stress response
protein translocation
|
|
gptkbp:significance
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
|
|
gptkbp:structure
|
C-terminal substrate-binding domain
conserved N-terminal ATPase domain
|
|
gptkbp:UniProtID
|
P0DMV8 (human HSPA1A)
|
|
gptkbp:bfsParent
|
gptkb:Heat_shock_protein
|
|
gptkbp:bfsLayer
|
6
|