|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
direct ligand binding
|
|
gptkbp:alternativeName
|
gptkb:ERBB2
gptkb:CD340
neu
p185
|
|
gptkbp:discoveredBy
|
gptkb:Axel_Ullrich
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:EC_number
|
2.7.10.1
|
|
gptkbp:encodedBy
|
gptkb:ERBB2_gene
|
|
gptkbp:Entrez_Gene_ID
|
2064
|
|
gptkbp:expressedIn
|
epithelial cells
|
|
gptkbp:form
|
heterodimers
homodimers
|
|
gptkbp:formsHeterodimerWith
|
gptkb:EGFR
gptkb:HER3
gptkb:HER4
|
|
gptkbp:fullName
|
human epidermal growth factor receptor 2
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
|
|
gptkbp:hasBiomarker
|
breast cancer prognosis
breast cancer therapy selection
|
|
gptkbp:hasClinicalTest
|
chromogenic in situ hybridization (CISH)
dual in situ hybridization (DISH)
fluorescence in situ hybridization (FISH)
immunohistochemistry (IHC)
silver in situ hybridization (SISH)
|
|
gptkbp:HGNC_ID
|
3430
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Her2
|
|
gptkbp:involvedIn
|
cell differentiation
cell growth
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:memberOf
|
gptkb:EGFR_family
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
|
|
gptkbp:OMIM
|
164870
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
gastric cancer
|
|
gptkbp:phosphorylationLeadsTo
|
activation of downstream signaling pathways
|
|
gptkbp:structure
|
extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
|
|
gptkbp:target
|
gptkb:ado-trastuzumab_emtansine
gptkb:pertuzumab
gptkb:trastuzumab
gptkb:lapatinib
|
|
gptkbp:UniProtID
|
gptkb:P04626
|
|
gptkbp:bfsParent
|
gptkb:Maja_Ardal
|
|
gptkbp:bfsLayer
|
6
|