|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:HMG-1
gptkb:amphoterin
|
|
gptkbp:associatedWith
|
gptkb:cancer
sepsis
autoimmune diseases
|
|
gptkbp:discoveredBy
|
M. Goodwin et al.
|
|
gptkbp:encodes
|
High mobility group protein B1
|
|
gptkbp:Entrez_Gene_ID
|
3146
ENSG00000189403
|
|
gptkbp:expressedIn
|
gptkb:nucleus
gptkb:cytoplasm
extracellular space
|
|
gptkbp:firstDescribed
|
1973
|
|
gptkbp:function
|
chromatin organization
regulation of transcription
inflammatory response
DNA binding
|
|
gptkbp:HGNC_ID
|
gptkb:HMGB1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HMGB1 gene
|
|
gptkbp:interactsWith
|
gptkb:TLR2
gptkb:TLR4
gptkb:nucleosomes
gptkb:gene
gptkb:p53_protein
histones
RAGE receptor
|
|
gptkbp:length
|
215 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q12
gptkb:chromosome_13
|
|
gptkbp:molecularWeight
|
~25 kDa
|
|
gptkbp:OMIM
|
163905
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Hmgb1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
methylation
acetylation
|
|
gptkbp:proteinFamily
|
high mobility group box (HMG-box)
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell migration
inflammation
|
|
gptkbp:UniProtID
|
gptkb:P09429
|
|
gptkbp:bfsParent
|
gptkb:HMGB1
|
|
gptkbp:bfsLayer
|
8
|