High Mobility Group Box 1

URI: https://gptkb.org/entity/High_Mobility_Group_Box_1
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:HMG-1
gptkb:amphoterin
high-mobility group protein 1
gptkbp:biologicalProcess cell migration
inflammation
tissue regeneration
apoptosis regulation
gptkbp:discoveredBy 1973
gptkbp:Entrez_Gene_ID 3146
gptkbp:expressedIn most tissues
gptkbp:extracellular_role immune response modulation
cytokine activity
damage-associated molecular pattern (DAMP)
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function chromatin organization
regulation of transcription
DNA binding
inflammatory mediator
gptkbp:gene gptkb:HMGB1
gptkb:HMGB1_gene
https://www.w3.org/2000/01/rdf-schema#label High Mobility Group Box 1
gptkbp:interactsWith gptkb:TLR4
gptkb:gene
histones
RAGE receptor
gptkbp:locatedOnChromosome gptkb:13q12
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
extracellular space
gptkbp:molecularWeight ~25 kDa
gptkbp:OMIM 163905
gptkbp:PDB 1HME
gptkbp:postTranslationalModification phosphorylation
methylation
acetylation
gptkbp:release_mechanism active secretion by immune cells
passive release from necrotic cells
gptkbp:role gptkb:Alzheimer's_disease
gptkb:cancer
sepsis
autoimmune diseases
rheumatoid arthritis
gptkbp:structure contains HMG-box domains
gptkbp:target therapeutic antibodies
small molecule inhibitors
gptkbp:UniProtID gptkb:P09429
gptkbp:bfsParent gptkb:HMGB1
gptkbp:bfsLayer 8