|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:HMGB1
|
|
gptkbp:biologicalProcess
|
apoptosis
DNA repair
cell migration
inflammation
immune response
tissue regeneration
autophagy
gene expression regulation
|
|
gptkbp:discoveredBy
|
M. Goodwin
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:encodedBy
|
gptkb:HMGB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000189403
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
High Mobility Group protein 1
|
|
gptkbp:function
|
regulation of transcription
DNA binding
chromatin remodeling
inflammatory mediator
|
|
gptkbp:gene
|
gptkb:HMGB1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HMG-1
|
|
gptkbp:interactsWith
|
gptkb:TLR4
gptkb:gene
histones
receptors for advanced glycation end products (RAGE)
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q12
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
extracellular space
|
|
gptkbp:molecularWeight
|
~25 kDa
|
|
gptkbp:OMIM
|
163905
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1HME
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
acetylation
|
|
gptkbp:RefSeq
|
NM_002128
|
|
gptkbp:role
|
gptkb:cancer
sepsis
autoimmune diseases
|
|
gptkbp:structure
|
contains two HMG-box domains
acidic C-terminal tail
|
|
gptkbp:UniProtID
|
gptkb:P09429
|
|
gptkbp:usedAs
|
biomarker
therapeutic target
|
|
gptkbp:bfsParent
|
gptkb:HMGB1
|
|
gptkbp:bfsLayer
|
8
|