Hypoxia-inducible factor 1-alpha
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
transcription factor |
| gptkbp:alias |
gptkb:HIF-1α
gptkb:bHLHe78 |
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
angiogenesis ischemia |
| gptkbp:degradedBy |
gptkb:proteasome
gptkb:prolyl_hydroxylase gptkb:von_Hippel-Lindau_protein oxygen levels |
| gptkbp:domain |
PAS domain
basic helix-loop-helix domain |
| gptkbp:encodedBy |
gptkb:HIF1A_gene
|
| gptkbp:firstDescribed |
1995
|
| gptkbp:formsComplexWith |
gptkb:HIF-1β
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
regulation of response to hypoxia
|
| https://www.w3.org/2000/01/rdf-schema#label |
Hypoxia-inducible factor 1-alpha
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:locatedOnChromosome |
14q23.2
|
| gptkbp:molecularWeight |
~93 kDa
|
| gptkbp:PDB |
4H6J
|
| gptkbp:phosphorylates |
yes
|
| gptkbp:regulates |
VEGF expression
expression of hypoxia-responsive genes erythropoietin expression glycolytic enzymes |
| gptkbp:UniProtID |
Q16665
|
| gptkbp:bfsParent |
gptkb:HIF-1α
|
| gptkbp:bfsLayer |
7
|