|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BHLHE78
gptkb:MOP1
gptkb:PASD8
gptkb:bHLHe78
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
angiogenesis
ischemia
|
|
gptkbp:biologicalProcess
|
angiogenesis
DNA-binding transcription factor activity
response to hypoxia
cellular response to decreased oxygen levels
|
|
gptkbp:clinicalTrialPhase
|
yes
|
|
gptkbp:discoveredBy
|
gptkb:Gregg_L._Semenza
|
|
gptkbp:encodes
|
gptkb:hypoxia-inducible_factor_1-alpha
|
|
gptkbp:Entrez_Gene_ID
|
3091
ENSG00000100644
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:firstDescribed
|
1995
|
|
gptkbp:function
|
transcription factor activity
regulation of cellular response to hypoxia
|
|
gptkbp:HGNC_ID
|
4910
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HIF1A gene
|
|
gptkbp:length
|
826 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_14
14q23.2
|
|
gptkbp:mRNA_length
|
~3.5 kb
|
|
gptkbp:mutationAssociatedWith
|
cancer progression
familial erythrocytosis
|
|
gptkbp:OMIM
|
603348
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Hif1a
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
glycolysis
HIF-1 signaling pathway
|
|
gptkbp:product
|
gptkb:HIF-1α
|
|
gptkbp:proteinFamily
|
basic helix-loop-helix-PAS family
|
|
gptkbp:regulates
|
gptkb:erythropoietin_gene
gptkb:VEGF_gene
prolyl hydroxylation
VHL protein interaction
glycolytic genes
oxygen-dependent degradation
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
anti-cancer drugs
hypoxia mimetics
|
|
gptkbp:UniProtID
|
Q16665
|
|
gptkbp:bfsParent
|
gptkb:HIF-1α
|
|
gptkbp:bfsLayer
|
7
|