|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CYP2D
gptkb:P450DB1
gptkb:debrisoquine_4-hydroxylase
|
|
gptkbp:associatedWith
|
adverse drug reaction
poor metabolizer phenotype
ultrarapid metabolizer phenotype
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000100197
1565
|
|
gptkbp:enzymeCommissionNumber
|
1.14.14.1
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
brain
liver
|
|
gptkbp:function
|
drug metabolism
oxidation of xenobiotics
|
|
gptkbp:hasVariant
|
CYP2D6*10
CYP2D6*17
CYP2D6*4
CYP2D6*41
CYP2D6*2
|
|
gptkbp:HGNC_ID
|
3024
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HGNC:3024
|
|
gptkbp:locatedIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:locatedOnChromosome
|
22
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:locusType
|
gptkb:22q13.2
|
|
gptkbp:name
|
gptkb:cytochrome_P450_family_2_subfamily_D_member_6
|
|
gptkbp:OMIM
|
124030
|
|
gptkbp:orthologIn
|
gptkb:mouse_Cyp2d22
gptkb:rat_Cyp2d1
|
|
gptkbp:pathway
|
drug metabolism - cytochrome P450
metabolism of xenobiotics by cytochrome P450
tamoxifen metabolism
codeine metabolism
tricyclic antidepressant metabolism
|
|
gptkbp:proteinFamily
|
gptkb:cytochrome_P450
|
|
gptkbp:RefSeq
|
gptkb:NM_000106
|
|
gptkbp:relatedTo
|
gptkb:paroxetine
gptkb:tricyclic_antidepressants
gptkb:dextromethorphan
gptkb:codeine
gptkb:SSRIs
gptkb:tamoxifen
gptkb:metoprolol
beta blockers
opioids
antipsychotics
|
|
gptkbp:symbol
|
gptkb:CYP2D6
|
|
gptkbp:UniProtID
|
P10635
|
|
gptkbp:bfsParent
|
gptkb:dopamine_receptor_D2
|
|
gptkbp:bfsLayer
|
7
|