|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeSplicing
|
gptkb:D2L_(long_isoform)
gptkb:D2S_(short_isoform)
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
addiction
bipolar disorder
schizophrenia
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:DRD2_gene
|
|
gptkbp:enemyOf
|
gptkb:chlorpromazine
gptkb:quinpirole
gptkb:haloperidol
gptkb:risperidone
bromocriptine
|
|
gptkbp:expressedIn
|
gptkb:striatum
gptkb:pituitary_gland
gptkb:nucleus_accumbens
gptkb:olfactory_tubercle
|
|
gptkbp:family
|
gptkb:dopamine_receptor_family
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
inhibitory neurotransmission
dopamine receptor activity
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3024
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
dopamine receptor D2
|
|
gptkbp:ligand
|
dopamine
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11q23.2
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:OMIM
|
126450
|
|
gptkbp:orthologIn
|
gptkb:mouse_Drd2
gptkb:rat_Drd2
|
|
gptkbp:PDB
|
gptkb:6LUQ
6CM4
|
|
gptkbp:regulates
|
cognition
emotion
motor control
endocrine signaling
prolactin secretion
reward pathway
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:subfamily
|
gptkb:D2-like_receptors
|
|
gptkbp:target
|
antipsychotic drugs
dopaminergic drugs
|
|
gptkbp:type
|
inhibits adenylyl cyclase
activates potassium channels
inhibits calcium channels
|
|
gptkbp:UniProtID
|
P14416
|
|
gptkbp:bfsParent
|
gptkb:Dopamine
|
|
gptkbp:bfsLayer
|
6
|